Stability of sulfonylureas blood speciemens and water standards
- مجال مشروع البحث–الرئيسي
- العلوم الطبية والصحية
- مجال مشروع البحث–الثانوي
- التحاليل الطبية
- المؤسسة العلمية
- الجامعة الأردنية
- المحافظة
- عمان
- قيمة الدعم
- JD3979.952
- سنة الدعم
- 2001
- حالة المشروع
- منشور في مؤتمر
- البحث منشور
- Battah A, M.D, Ph.D and Hadidi, K Ph.D. Stability of sulfonylureas in stored postmortem blood specimens and water standards. Presented in 2004 FBI
- ملخص عن مشروع البحث
- Stability of three commonly prescribed sulfonylureas (glipizide, chlopropamide and glibenclamide) in postmortem blood and water stored at –20, 4, and 25°C were evaluated over a 1-year period. The drugs were analyzed simultaneous by utilizing solid phase extraction techniques and were identified and quantified by high performance liquid chromatography. Significant loss of Glibenclamide was noticed at second and third week of storage at 25 and 4°C respectively. The decrease was gradual but no clear pattern could be established. At the end of the 1-year storage period at either 4 or 25°C, the level of glibenclamide was 37% and 46% of its initial value in water and postmortem blood samples respectively. After 6-months storage time a significant decrease in the levels glipizide and chlopropamide occurred, that ranged from 67.5 to 84.1% of their initial values at the end of the 1-year of storage. Storage at -20°C showed the least loss of drug concentration. Authentic samples of these drugs showed similar results. This study supports the importance of paying careful attention to using prepared water drug standards even when stored in cold conditions. In order to obtain reliable results of drug analysis and drug stability in biological samples, such studies should be considered after prolonged sample storage time. The best storage temperature to keep water standards and blood samples for the investigated drugs with sufficient stability was found to be at -20°C.
https://www.researchgate.net/publication/273005535_Stability_of_sulfonylureas_in_stored_postmortem_blood_specimens_and_water_standards
-
الاسم الكامل للباحث الرئيسي
د.عبدالقادر بطاح
الجنس
ذكر
المشاريع ذات صلة