مؤسسة عبد الحميد شومان > البحث العلمي > صندوق دعم البحث العلمي

الرجوع

The Associations Among Obesity, Certain Inflammatory Markers and Carotid Intima-Media Thickness in a

مجال مشروع البحث–الرئيسي: العلوم الطبية والصحية
مجال مشروع البحث–الثانوي: الامراض المزمنة
المؤسسة العلمية: الجامعة الأردنية
المحافظة: عمان
قيمة الدعم: JD4594.71
سنة الدعم: 2015
حالة المشروع: منتهي مع النشر
البحث منشور: (1) Al-Shorman, A., Al-Domi, H., & Faqih, A. (2017). Markers of subclinical atherosclerosis in schoolchildren with obesity and metabolic syndrome. Swiss medical weekly, 147(2122). (2) Al-Shorman, A., Al-Domi, H., & Al-Atoum, M. (2018). The associations of body composition and anthropometric measures with carotid intima-media thickness in obese and non-obese schoolchildren: A possible predictor for cardiovascular diseases. Vascular, 26(3), 285-290. (3) Al-Domi, H., & Al-Shorman, A. (2019). Increased waist circumference is associated with subclinical atherosclerosis in schoolchildren. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 13(1), 264-269. (4) Al-Shorman, A., AlKhatib, B., & Al-Domi, H. (2020). The association between fat mass and subclinical atherosclerosis in healthy schoolchildren. Clinical nutrition ESPEN, 37, 87-92.
ملخص عن مشروع البحث: 1. BACKGROUND:Although increased carotid intima-media thickness (cIMT), soluble adhesion molecules and proinflammatory biomarkers are strongly implicated in the development of atherosclerotic lesions, the role of obesity and metabolic syndrome (MetS) in atherogenicity and inflammation among schoolchildren is not well investigated. AIM:To determine the levels of cIMT, endothelial dysfunction and inflammatory biomarkers in a group of schoolchildren with obesity and MetS. METHODS:Eighty-seven schoolchildren (age 10–15 years) were categorised into three groups: normal bodyweight group, obese group and severely obese with MetS group (17 boys and 12 girls in each group). Levels of cIMT were measured with high-resolution B-mode ultrasound. Serum proinflammatory cytokines interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β), and soluble adhesion molecules E-selectin, vascular cell adhesion molecule-1 (VCAM-1), and intercellular adhesion molecule-1(ICAM-1) were measured. RESULTS:Mean cIMT levels were significantly higher (p ≤0.05) among severely obese schoolchildren with MetS (0.49 ± 0.02 mm) compared with both the obese (0.43 ± 0.03 mm) and the normal bodyweight counterparts (0.36 ± 0.03 mm). Serum levels of IL-6, TNF-α, IL-1β, E-selectin, VCAM-1 and ICAM-1 were significantly higher (p ≤0.05) in severely obese with MetS and obese children compared with the normal bodyweight group. However, no significant differences (p >0.05) were found between the severely obese schoolchildren with MetS and the obese without MetS. CONCLUSIONS:Severely obese schoolchildren having MetS exhibited higher cIMT levels than obese and normal bodyweight counterparts. Biomarkers of inflammation and endothelial dysfunction were higher in obese schoolchildren, but biomarkers were not increased any further by the degree of obesity nor the MetS cluster. https://smw.ch/article/doi/smw.2017.14446 2. Background:Increased carotid intima-media thickness is one of the predictors of future cardiovascular diseases. However, it is still unknown which body composition parameter or anthropometric measure is the best predictor for carotid intima-media thickness change among children and young adolescents. Objective:To investigate the associations of body composition and anthropometric measures with carotid intima-media thickness among a group of obese and normal bodyweight schoolchildren. Methods:A total of 125 schoolchildren (10–15 years) were recruited from four public schools in Amman, Jordan. Of them, 60 (29 boys and 31 girls) were normal bodyweight students and 65 (35 boys and 30 girls) were obese students. Anthropometric measures, fat mass and fat-free mass were determined. Carotid intima-media thickness of the common artery was measured using high-resolution B-mode ultrasound. Results:Compared to normal bodyweight students, obese participants exhibited greater carotid intima-media thickness (mm) (0.45 ± 0.10 vs. 0.38 ± 0.08, p = 0.002) and fat-free mass (kg) (48.01 ± 11.39 vs. 32.65 ±7.65, p < 0.001). Pearson’s correlation coefficient and linear regression analysis revealed significant associations (p≤0.05) between mean carotid intima-media thickness and body mass index, waist circumference, hip circumference, waist-to-hip ratio, fat mass and fat-free mass. Stepwise linear regression analysis revealed that waist circumference was the only measure that was statistically significant (p ≤ 0.05) with mean carotid intima-media thickness (r2 = 0.129, p = 0.002). Conclusions:Obesity is related to greater carotid intima-media thickness and other cardiovascular risk factors among schoolchildren. Waist circumference is more sensitive in predicting increased carotid intima-media thickness than other body composition or anthropometric measures. Waist circumference measurement in the analysis of future studies assessing the cardiovascular risk among obese children is warranted. https://journals.sagepub.com/doi/abs/10.1177/1708538117735457 3. Background:Waist circumference (WC) is an indicator of adiposity; particularly visceral fat, cardiometabolic risk factors and related morbidity. The aim of this study was to determine the attribution of WC to increased carotid intima-media thickness (cIMT) and circulating levels of inflammation and endothelial dysfunction in schoolchildren. Methods:A total of 122 children (61 boys and 61 girls) aged 10–15 years were distributed into three groups: (i) the lower smoothed sex- and age-specific WC (LWC) group (ii) the middle smoothed sex- and age-specific WC (MWC) group, and (iii) the higher smoothed sex- and age-specific WC (HWC) group. Measurements of cIMT using high-resolution B-mode ultrasound, lipemic profile, blood pressure, serum proinflammatory cytokines and soluble adhesion molecules were performed. Results:Mean measured values in the HWC and/or MWC groups showed significantly higher values (p ≤ 0.05) of cIMT (mm), total cholesterol, triglycerides, low-density lipoprotein (LDL), blood pressure, interlukien-6 (IL-6), and interlukien-1 beta (IL-1β), vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1(ICAM-1) and E-selectin, and significantly lower values of high-density lipoprotein (HDL) as compared to the LWC group. Using multiple linear regression analysis of WC-SDS adjusted for BMI-SDS with the studied subclinical atherosclerosis risk, WC-SDS was significantly (p ≤ 0.05) associated with the variation in HDL (R2 = −0.12), LDL (R2 = 0.36), IL-6 (R2 = 0.26), and VCAM-1 (R2 = 0.26). Conclusions:Higher WC is positively associated with atherosclerosis risk factors including increased cIMT, a state of dyslipidemia, higher blood pressure and circulating levels of inflammation and adhesion molecules among schoolchildren. Waist circumference seems to be useful for the prediction of subclinical atherosclerosis in schoolchildren. https://www.sciencedirect.com/science/article/abs/pii/S1871402118303746 4. Background and aims:Childhood obesity is associated with increased risk of cardiovascular disease (CVD) later in life. The aims of this study were to investigate the change of atherosclerosis risk factors in three fat mass percentiles and to examine the association between fat mass and atherosclerosis risk factors among a group of schoolchildren. Methods:A total of 125 schoolchildren (64 boys) aged 10–15 years were distributed into three groups: (i) the lower fat mass (LFM) group, for participants who reported fat mass ≤50th percentile; (ii) the middle fat mass (MFM) group, for participants who reported fat mass >50th percentile and <75th percentile; and (iii) the higher fat mass (HFM) group for participants who reported ≥ 75th percentiles. Measurements of carotid intima-media thickness (cIMT) using high-resolution B-mode ultrasound, lipemic profile, blood pressure, serum proinflammatory cytokines and soluble adhesion molecules were performed. Results:Significant differences (p ≤ 0.05) were shown between the three groups in total cholesterol (TC), triglycerides (TG), LDL, interlukien-6 (IL-6), and interlukien-1 beta (IL-1β). Using multiple linear regression analysis of fat mass as the dependent variable with the studied subclinical atherosclerosis risk, fat mass was significantly (p ≤ 0.05) associated with the variation expressed in systolic blood pressure (β = 0.490), diastolic blood pressure (β = 0.470), TC (β = 0.399), TG (β = 0.306), HDL (β = −0.281), LDL (β = 0.446), E-selectin (β = 0.314), and cIMT (β = 0.257). Conclusion:Higher fat mass is associated with increased risk of atherosclerosis in schoolchildren. Atherosclerosis risk factors including biomarkers of inflammation, endothelial dysfunction, a state of dyslipidemia, increased cIMT, and high blood pressure were associated with fat mass. Studies evaluating the appropriate fat mass cut-off points in children and adolescents are needed. https://www.sciencedirect.com/science/article/abs/pii/S2405457720300590